First of all, there is no "state highway 220", it is US 220. Second, US 220 covers a lot of miles between the NC and WV borders, so a generic statement like this isn't helpful to anyone. Specific locations are what is being sought here.

Well, another thought on this: I recently heard a TV commentator speaking of his having to take the "Andy Griffin Parkway" from Greensboro to Blacksburg to cover sporting events.